Humans are diverse, and this diversity influences the properties of our cells, as well as our developmental processes, and disease mechanisms, diagnoses, and treatments. The impact of population-specific genetic variation on disease risk and healthcare is widely appreciated, and this can contribute to health disparities. To build a single cell reference atlas suitable for diverse population groups, we seek to characterise the impact of genes and environment on molecular traits in cells from diverse individuals across the globe. Specifically, we aim to uncover the influence of genetics, ancestry, age and sex on human phenotypes in health and disease.

We are looking for team members who will develop cutting-edge AI/machine learning methods and pipelines to integrate and interrogate gene expression and regulatory profiles of >10 million cells from thousands of donors. Your work will help establish a healthy immune baseline for disease comparisons, and craft and curate atlases of human cells that will transform our understanding of human biology. Successful candidates for this position will have the opportunity to collaborate with, learn from, and contribute to teams across the world studying diverse donors and tissues, including the Human Cell Atlas bionetworks.

Requirements:

• PhD with experience in computational biology
• Mathematical sophistication
• Programming skills in R/Python
• Strong communication skills
• Post-doctoral candidates should have a strong track record, including impactful publications

To apply, please e-mail your CV and names of references to: prabhakars@gis.a-star.edu.sg, sankarans@gis.a-star.edu.sg

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.