Job Description
The Cardiovascular and Metabolic Disorders (CVMD) Programme at Duke-NUS houses state-of-the-art technologies for profiling mitochondrial function, RNA-based therapeutics, and metabolic adaptations in human patients and relevant model systems. The programme undertakes translational and clinical research in cardiovascular and metabolic disorders, with a strong emphasis on therapeutic development, including lipid nanoparticle (LNP)-based RNA delivery platforms.

We are seeking a highly motivated (Senior) Research Assistant to support RNA therapeutics programs, with lipid nanoparticle (LNP) formulation and delivery as a core component of the role. The successful candidate will play a key hands-on role in RNA synthesis/handling, LNP formulation and optimization, and downstream in vitro and in vivo validation in cardiovascular disease models.

• Perform tasks and support all aspects of assigned research projects under the supervision of the Principal Investigator or designate.
• Conduct accurate monitoring, documentation, and reporting of experimental results and research findings.
• Evaluate and interpret data, and prepare oral presentations, written reports, scientific manuscripts, and literature reviews.
• Assist researchers in aspects of project management, laboratory demonstrations, and guidance of undergraduate or medical students.
• Establish and maintain work procedures to ensure high laboratory efficiency, productivity, and compliance with safety protocols.
• Provide technical support, assist with general laboratory upkeep, and support ongoing research projects.
• Perform other related duties incidental to the work described.

Job Requirements

• Bachelor's or Master's degree in Life Sciences, Biomedical Science, Chemistry, Materials Science, or related fields.
• Minimum of 2 years of relevant research experience in RNA biology, RNA synthesis, RNA therapeutics, or lipid nanoparticle (LNP) delivery.
• Demonstrated hands-on expertise in molecular biology techniques, cellular assays, ELISA, and/or histology.
• Experience with in vitro assays and/or in vivo animal work (rodents) is preferred.
• Strong laboratory skills with good experimental troubleshooting capability.
• Knowledge of scientific background relevant to cardiovascular and translational research.
• Strong team player with the ability to prioritise, multitask, and work collaboratively in a diverse environment.
• Good communication, documentation, and organizational skills.
• RCULA certification will be an advantage.

We regret that only shortlisted candidates will be notified.