SMART is a major research enterprise established by the Massachusetts Institute of Technology (MIT) in partnership with the National Research Foundation of Singapore (NRF). SMART serves as an intellectual hub for international research collaborations, not only between MIT and Singapore, but also involving researchers from the region and beyond. At SMART, we identify and carry out research on critical problems of societal importance. SMART is a magnet attracting and anchoring global research talent, while simultaneously instilling and promoting a culture of translational research and entrepreneurship in Singapore. Five interdisciplinary research groups (IRGs) have been established to date: BioSystems and Micromechanics (BioSym), Centre for Environmental Sensing and Modeling (CENSAM), Future Urban Mobility (FM), Infectious Diseases (ID) and Low Energy Electronics Systems (LEES).